{"id":11078,"date":"2019-03-08T23:00:15","date_gmt":"2019-03-08T23:00:15","guid":{"rendered":"https:\/\/www.engineernewsnetwork.com\/blog\/?p=11078"},"modified":"2019-03-07T18:17:15","modified_gmt":"2019-03-07T18:17:15","slug":"engineering-innovation-brings-hope-for-a-parkinsons-cure","status":"publish","type":"post","link":"https:\/\/www.engineernewsnetwork.com\/blog\/engineering-innovation-brings-hope-for-a-parkinsons-cure\/","title":{"rendered":"Engineering innovation brings hope for a Parkinson\u2019s cure"},"content":{"rendered":"\n<p>Global engineering company Renishaw has built a device that has been used in a ground-breaking clinical trial.&nbsp;<\/p>\n\n\n\n<p>Manufactured by Renishaw on behalf of the North Bristol NHS Trust, the device enabled the precise delivery of a new drug candidate, Glial Cell Line Derived Neurotrophic Factor (GDNF) with the hope of regenerating dying dopamine brain cells in people with Parkinson\u2019s and thereby improve their symptoms.<\/p>\n\n\n\n<p>The results of the trial feature in a two-part BBC Two documentary, <em>The Parkinson\u2019s Drug Trial: A Miracle Cure?<\/em><\/p>\n\n\n\n<p>Renishaw worked with Consultant Neurosurgeon, Professor Steven Gill, to manufacture the novel drug delivery system, which offers a practical method to bypass the blood-brain barrier.&nbsp;<\/p>\n\n\n\n<p>During the trial, 42 patients had the additively manufactured titanium port embedded into their skull through which GDNF could be delivered via micro-catheters to the putamen, a critical region of the brain for motor function. <\/p>\n\n\n\n<p>The device is implanted using the <strong><a href=\"https:\/\/www.renishaw.com\/en\/neuroinfuse-drug-delivery-system--42358\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"Renishaw neuromate surgical robot (opens in a new tab)\">Renishaw neuromate surgical robot<\/a><\/strong>, which positions four catheters into the brain.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1016\" src=\"https:\/\/www.engineernewsnetwork.com\/blog\/wp-content\/uploads\/2019\/03\/REC323-Image-of-4-catheters-Credit-Chris-Marshall-Mint-Motion-1-1024x1016.jpg\" alt=\"\" class=\"wp-image-11081\" srcset=\"https:\/\/www.engineernewsnetwork.com\/blog\/wp-content\/uploads\/2019\/03\/REC323-Image-of-4-catheters-Credit-Chris-Marshall-Mint-Motion-1-1024x1016.jpg 1024w, https:\/\/www.engineernewsnetwork.com\/blog\/wp-content\/uploads\/2019\/03\/REC323-Image-of-4-catheters-Credit-Chris-Marshall-Mint-Motion-1-150x150.jpg 150w, https:\/\/www.engineernewsnetwork.com\/blog\/wp-content\/uploads\/2019\/03\/REC323-Image-of-4-catheters-Credit-Chris-Marshall-Mint-Motion-1-300x298.jpg 300w, https:\/\/www.engineernewsnetwork.com\/blog\/wp-content\/uploads\/2019\/03\/REC323-Image-of-4-catheters-Credit-Chris-Marshall-Mint-Motion-1-768x762.jpg 768w, https:\/\/www.engineernewsnetwork.com\/blog\/wp-content\/uploads\/2019\/03\/REC323-Image-of-4-catheters-Credit-Chris-Marshall-Mint-Motion-1-800x794.jpg 800w, https:\/\/www.engineernewsnetwork.com\/blog\/wp-content\/uploads\/2019\/03\/REC323-Image-of-4-catheters-Credit-Chris-Marshall-Mint-Motion-1-100x100.jpg 100w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption>Global engineering company Renishaw has built a device that has been used in a ground-breaking clinical trial. Image to Chris Marshall\/Mint Motion.<\/figcaption><\/figure>\n\n\n\n<p>The trial was funded by Parkinson\u2019s UK with support from the Cure Parkinson\u2019s Trust and in association with the North Bristol NHS Trust.&nbsp;<\/p>\n\n\n\n<p>Results announced on February 27th showed that the drug delivery system performed effectively and reliably and a similar device, developed by Renishaw called \u2018neuroinfuse\u2122\u2019, is now being used in other clinical trials.<\/p>\n\n\n\n<p>\u201cThis trial has shown that we can safely and repeatedly infuse drugs directly into patient\u2019s brains over months or years through a small implanted port that emerges through the skin behind the ear,\u201d explained Professor Steven Gill. \u201cThis is a significant breakthrough in our ability to treat neurological conditions, such as Parkinson\u2019s because most drugs that might work cannot cross from the bloodstream into the brain due to a natural protective barrier.&nbsp;<\/p>\n\n\n\n<p>\u201cEven at a low dose we have seen evidence of patient improvement, which is incredibly encouraging,\u201d added Professor Gill. \u201cNow we need to move towards a definitive clinical trial using higher doses and this work urgently needs funding. I believe that this approach could be the first neuro-restorative treatment for people living with Parkinson\u2019s which is, of course, an extremely exciting prospect.\u201d<\/p>\n\n\n\n<p>\u201cIt has been a privilege to work alongside the study team and with the participants in this ambitious trial,\u201d explained Paul Skinner, General Manager for Neurological Products at Renishaw.&nbsp; \u201cWe are very encouraged that there were changes in the brain scans, demonstrating that GDNF is having an effect, and that the delivery system achieved precision administration of drugs into the brain.<\/p>\n\n\n\n<p>\u201cThis provides great potential for using the drug delivery system, being developed by Renishaw, for future Parkinson\u2019s studies and experimental treatments for other neurodegenerative diseases and brain tumours.\u201d<\/p>\n\n\n\n<p>The findings of the trials can be found in Brain and the <em>Journal of Parkinson\u2019s disease<\/em>.&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Global engineering company Renishaw has built a device that has been used in a ground-breaking clinical trial.&nbsp; Manufactured by Renishaw on behalf of the North Bristol NHS Trust, the device enabled the precise delivery of a new drug candidate, Glial Cell Line Derived Neurotrophic Factor (GDNF) with the hope of regenerating dying dopamine brain cells &hellip;<\/p>\n","protected":false},"author":1,"featured_media":11080,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[105,199],"tags":[5765],"class_list":["post-11078","post","type-post","status-publish","format-standard","has-post-thumbnail","","category-design","category-news-views-and-opinion","tag-parkinsons"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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