{"id":25824,"date":"2023-08-10T09:30:00","date_gmt":"2023-08-10T08:30:00","guid":{"rendered":"https:\/\/www.engineernewsnetwork.com\/blog\/?p=25824"},"modified":"2023-08-09T12:51:03","modified_gmt":"2023-08-09T11:51:03","slug":"next-generation-accuracy-for-microfluidic-control","status":"publish","type":"post","link":"https:\/\/www.engineernewsnetwork.com\/blog\/next-generation-accuracy-for-microfluidic-control\/","title":{"rendered":"Next-generation accuracy for microfluidic control"},"content":{"rendered":"\n

Accurate microfluidic dosing is essential for life science and genomics research, as well as the administration of medical care. For OEMs developing microfluidic dosing machines, accurate valve control ensures precise results. However, to specify the optimum valve system, consideration of criteria from material compatibility to manifold integration is vital for ensuring repeatable accuracy. Troy Stehr discusses the requirements for accurate microfluidic control<\/strong><\/p>\n\n\n\n

Reagents are integral to research in life sciences, and the result of how they chemically react with other substances, by measuring, detecting, or examining an outcome, is vital for the development of medical treatments. Essential to this process is accurate, repeatable control of reagent dosing, in microfluidic volumes down to 1\u00b5l and below. These same requirements apply to genomics, such as conducting a polymerase chain reaction (PCR) technique to amplify select DNA segments. Accurate and reliable microfluidic dosing can also be life dependent for many medical applications.<\/p>\n\n\n\n

Today, machines can replace manual handling of pipettes with more accurate and consistent dosing. Automation not only saves the time of skilled humans, but fast dosing of multiple channels improves productivity too. To achieve these results, there\u2019s high reliance on a dosing machine\u2019s valve control system.<\/p>\n\n\n\n

Open or closed loop?<\/strong><\/p>\n\n\n\n

Understanding the required dosing accuracy is typically the starting point in valve system specification. Patients are treated or diagnosed based on lab results, so the accuracy requirement of the intended assessment determines the dosing precision the machine has to provide. Optimising volume use is also important to control costs, both in the use and the disposal of  some very expensive reagents and involved substances.<\/p>\n\n\n\n

Sufficient for many microfluidic applications, time-pressure dosing provides precision of <1% with repeatable volumetric accuracy between 2-5%. With this technique, media flow is controlled by valve opening or closing for a defined time for each switching cycle. Using air or an inert gas to pressurise the fluid reservoir, combined with a dosing valve, this technique enables controlled dosing down to single digit \u00b5l (microlitre) volumes.<\/p>\n\n\n

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Accurate microfluidic dosing is essential for life science and genomics research, as well as the administration of medical care<\/figcaption><\/figure>\n<\/div>\n\n\n

B\u00fcrkert\u2019s microvalves for time pressure dosing are capable of ~10\u03bcs (microsecond) control signal steps for high accuracy valve control lower than 1%. If even greater accuracy is required, B\u00fcrkert also provides closed loop valve control. These systems incorporate a sensor, providing feedback on actual valve status that enables constant adjustment to valve opening\/closing rates. Alternatively, an open loop system, like time-pressure dosing, operates purely on the valve\u2019s input command, irrespective of changes that could impact its switching time, and as a result, the actual dosing volume.<\/p>\n\n\n\n

\u03bcl and nl dosing accuracy<\/strong><\/p>\n\n\n\n

Closed loop systems often operate on the Coriolis principle, where vibrations of a liquid-carrying tube are measured with a resulting flow-proportional output. With this technology, B\u00fcrkert\u2019s mass flow controller\/meter can achieve dosing accuracy at levels below 1ml. However, a new innovation is set to become the first device available on the market with \u03bcl (microlitre) measurement and closed loop control accuracy, with a differential pressure sensor integrated in a device together with a valve. B\u00fcrkert\u2019s new dosing system measures and controls drops down to 50nl (nanolitres), with closer than 1% accuracy measured over millions of cycles completed in trials so far.<\/p>\n\n\n\n

Crucial to control over time is compatibility between the media and the material fluid block and seals, especially when multiple reagents and substances are involved. Depending on the media properties, different seal materials might be required and their selection requires careful consideration. Compatibility challenges can result in swollen seals, through to rupture over time, and when dealing with microfluidics, resulting in control problems are amplified. Within B\u00fcrkert\u2019s system, PEEK, used for valve bodies, and the sealing material FFKM or EPDM are the only wetted materials.<\/p>\n\n\n\n

Precision-engineered manifolds<\/strong><\/p>\n\n\n\n

To separate and control media flow, the valve system requires a manifold array with the number of inlets and outlets to suit the variety of required substances. Incorporating bespoke manifold design and manufacture with the selected valve is advantageous, particularly for microfluidic applications, to ensure optimised pressure management and heat exchange properties. As per valve design, the manifold is also subject to materials compatibility, so relying on the same vendor gives greater security in an efficient outcome. B\u00fcrkert precision engineers bespoke plastic injection moulded manifolds specific for microfluidic control applications.<\/p>\n\n\n\n

To optimise productivity, 10 or even more channels might be required, with high-speed dispensing. Combined with repeatable accuracy, to achieve system reliability over millions of valve cycles, a remote diagnostics capability, enabled by Industry 4.0 Ethernet communications, confirms actual valve operation data. Not only does this capability remove the time required for a physical human check, it provides a certainty, unattainable by a manual inspection alone, that the well plates are filled with the right volume and proportion of reagents.<\/p>\n\n\n\n

Troy Stehr is Industry Account Manager for Lab & MedTech applications at fluid control specialist B\u00fcrkert. http:\/\/www.burkert.co.uk<\/p>\n","protected":false},"excerpt":{"rendered":"

Accurate microfluidic dosing is essential for life science and genomics research, as well as the administration of medical care. For OEMs developing microfluidic dosing machines, accurate valve control ensures precise results. However, to specify the optimum valve system, consideration of criteria from material compatibility to manifold integration is vital for ensuring repeatable accuracy. Troy Stehr …<\/p>\n","protected":false},"author":1,"featured_media":25825,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[199],"tags":[1699,11908],"class_list":["post-25824","post","type-post","status-publish","format-standard","has-post-thumbnail","","category-news-views-and-opinion","tag-burkert","tag-microfluidic-control"],"yoast_head":"\nNext-generation accuracy for microfluidic control - Engineer News Network<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.engineernewsnetwork.com\/blog\/next-generation-accuracy-for-microfluidic-control\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Next-generation accuracy for microfluidic control - Engineer News Network\" \/>\n<meta property=\"og:description\" content=\"Accurate microfluidic dosing is essential for life science and genomics research, as well as the administration of medical care. 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